Oh! I like this one - I've got an idea incubating quite nicely.
a) I've always wondered about the ecology of dragons, like how did Smaug survive dormant and unfed for so many years, and where do they get their fire from and what use do they have for gold.
b) I was fascinated by the phrase "Tickling the Dragon's tail" used by Los Alamos scientists to describe dangerous experiments with nuclear cores - which led to one famous fatal accident.
I wouldn't want to give too many spoilers for where those two thoughts are taking me, I just hope I can make it fly!